Patrick Mahomes an Underdog at Home For First Time In Career, Against Bills

The full 2022 NFL schedule has been released and for Buffalo Bills fans, it's quite the schedule to say the least.

The Bills will play five primetime games, on Thanksgiving for the third time in four years, and on Christmas Eve.

The Bills will open the season on Thursday Night Football against the defending Super Bowl champs, the Los Angeles Rams. It will be the Bills first time playing in the week one TNF slot.

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The Bills will travel Detroit to play the Lions on Thanksgiving at 12:30 pm. The Bills have played on Thanksgiving three out of four years and each time, in a different time slot (12:30, 4:30, 8:00 pm).

The most anticipated game of the season for the Bills is probably the week 6 matchup at the Kansas City Chiefs at 4:25 pm.

If fans are wondering why that AFC Divisional round rematch is not on Sunday Night Football, it's likely because CBS protected it since both are AFC teams and it's a ratings bonanza.

The Bills have opened up as 1.5 point favorites at the Chiefs. It's the first time in Patrick Mahomes' career that he is an underdog at home. Mahomes has been starting for Kansas City since the 2018 season.

It's only May, so the line will change by the time October rolls around, but this goes to show just how confident Vegas and oddsmakers are in the Bills being the best team in the NFL this season.

The Chiefs traded away star wide receiver Tyreek Hill in March and have a new set of offensive weapons, but tight end Travis Kelce remains.

The Bills only play four 1 pm home games and just one before week 10.